Improved efficiency of photo-induced synthetic reactions enabled by advanced photo flow technologies
Fukuyama, T.; Kasakado, T.; Hyodo, M.; Ryu, I.
Photochem. Photobiol. Sci. 2022, 21, 761-775
High-speed C-H chlorination of ethylene carbonate using a new photoflow setup
Kasakado, T.; Fukuyama, T.; Nakagawa, T.; Taguchi, S.; Ryu, I.
Beilstein J. Org. Chem. 2022, 18, 152-158.
Using High-Power UV-LED to Accelerate a Decatungstate-Anion-Catalyzed Reaction: A Model Study for the Quick Oxidation of Benzyl Alcohol to Benzoic Acid Using Molecular Oxygen.
Hyodo, M.; Iwano, H.; Kasakado. T.; Fukuyama, T.; Ryu, I.
Micromachines. 2021, 12, 1307-1315.
Greener Synthesis of Pristane by Flow Dehydrative Hydrogenation of Allylic Alcohol Using a Packed-Bed Reactor Charged by Pd/C as a Single Catalyst, Kasakado,T.; Hirobe, Y.; Furuta, A.; Hyodo, M.; Fukuyama, T.; Ryu, I. Molecules 2021, 26, 5845-5853.
Flow Friedel-Crafts alkylation of 1-adamantanol with arenes using HO-SAS as an immobilized acid catalyst
Kasakado, T.; Hyodo, M.; Furuta, A.; Kamardine, A.; Ryu, I.; Fukuyama, T.; J. Chin. Chem. Soc. 2020, 67, 2253-2257.
Revisiting Hydroxyalkylation of Phenols with Cyclic Carbonates, S.-C. Kao, Y.-C. Lin, I. Ryu, Y.-K. Wu, Adv. Synth. Catal. 2019, 361, 3639-3644.
Kinetically Controlled Fischer Glycosidation under Flow Conditions: A New Method for Preparing Furanosides, Masui, S.; Manabe, Y.; Hirao, K.; Shimoyama, A.; Fukuyama, T.; Ryu, I.; Fukase, K. Synlett 2019, 30, 397-400.
Formal Total Synthesis of L‑Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System, Inuki, S.; Sato, K.; Fukuyama, T.; Ryu, I.; Fujimoto, Y. J. Org. Chem., 2017, 82, 1248−1253.
Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane, Furuta, A.; Hirobe, Y.; Fukuyama, T.; Ryu, T.; Manabe, Y.; Fukase, K. Eur. J. Org. Chem., 2017, 1365–1368.
Efficient Flow Fischer Esterification of Carboxylic Acids with Alcohols Using Sulfonic Acid-Functionalized Silica as Supported Catalyst, Furuta, A.; Fukuyama, T.; Ryu, I. Bull. Chem. Soc. Jpn., 2017, 90, 607–612.
A greener process for flow C–H chlorination of cyclic alkanes using in situ generation and on-site consumption of chlorine gas, Fukuyama, T.; Tokizane, M.; Matsui, M.; Ryu, I. React. Chem. Eng., 2016, 1, 613–615.
Flow Update for a Cossy Photocyclization, Fukuyama, T.; Fujita, Y.; Rashid, M. A.; Ryu, I. Org. Lett., 2016, 18, 5444−5446.
カルボニル化の新手法/ Innovative Carbonylation Methods Kawamoto, T.; Fukuyama, T.; Ryu, I. 有機合成化学協会誌/ J. Synth. Org. Chem. Jpn. 2014, 72, 493.
Carbonylation in microflow: close encounters of CO and reactive species Fukuyama, T., Totoki, T., Ryu, I. Green Chem., 2014, 16, 2042
Revisiting the Bromination of C-H Bonds with Molecular Bromine by Using a Photo-Microflow System, Manabe, Y.; Kitawaki, Y.; Nagasaki, M.; Fukase, K.; Matsubara, H.; Hino, Y.; Fukuyama, T.; Ryu, I. Chem. Eur. J., 2014, 20, 12750.
Flow Update for the Carbonylation of 1-Silyl-Substituted Organolithiums under CO Pressure, Fukuyama, T.; Totoki, T.; Ryu, I. Org. Lett., 2014, 16, 5632.
Flow Carbonylation Using Near-stoichiometric Carbon Monoxide. Application to Heck Carbonylation, Akinaga, H.; Masaoka, N.; Takagi, K.; Ryu, I.; Fukuyama, T. Chem.Lett., 2014, 43, 1456.
Flow Giese Reaction Using Cyanoborohydride as a Radical Mediator, Fukuyama, T.; Kawamoto, T.; Kobayashi, M.; Ryu, I. Beilstein J. Org. Chem., 2013, 9, 1791.
Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source, Brancour, C., Fukuyama, T.; Mukai, Y.; Skrydstrup, T.; Ryu, I., Org. Lett., 2013, 15, 2794.
100 Gram Scale Synthesis of a Key Intermediate of Matrix Metalloproteinase Inhibitor in a Continuous-Flow System Based on a Copper-Free Sonogashira Reaction Using an Ionic Liquid as a Catalyst Support, Fukuyama, T.; Rahman, M. T.; Sumino, Y.; Ryu, I. Synlett, 2012, 23, 2279.
有機合成化学協会誌  Vol. 70 (2012) No. 9 p. 896-907
Nitroxide-Mediated Polymerization of Styrene, Butyl Acrylate, or Methyl Methacrylate by Microflow Reactor Technology, Fukuyama, T.; Kajihara, Y.; Ryu, I.; Studer, A., Synthesis 2012, 44, 16 pp. 2555 – 2559.
Koch–Haaf Reaction of Adamantanols in an Acid-tolerant Hastelloy-made Microreactor, Fukuyama, T.; Mukai, Y.; Ryu, I. Beilstein J. Org. Chem., 2011, 7, 1288.
Continuous Microflow [2 + 2] Photocycloaddition Reactions Using Energy-saving Compact Light Sources, Fukuyama, T.; Kajihara, Y.; Hino, Y.; Ryu, I.; J. Flow Chem., 2011, 1, 40.
Microflow photo-radical chlorination of cycloalkanes , Matsubara, H.; Hino, Y.; Tokizane, M.; Ryu, I., Chemical Engineering Journal, 2011, 167, 567.
Monolithic and Flexible Polyimide Film Microreactors for Organic Microchemical Applications Fabricated by Laser Ablation, Min, K. I.; Lee, T. H.; Park, C. P.; Wu, Z. W.; Girault, H. H.; Ryu, I.; Fukuyama, T., Mukai, Y., Kim, D. P., Angew. Chem. Int. Ed., 2010, 49, 7063.
Addition of Allyl Bromide to Phenylacetylene Catalyzed by Palladium on Alumina and its Application to a Continuous Flow Synthesis, Fukuyama, T.; Kippo, T.; Ryu, I.; Sagae, T. Research on Chemical Intermediates, 2009, 35, 1053.
Microflow Radical Carboaminoxylations with a Novel Alkoxyamine Wienhoefer, I. C.; Studer, A.; Rahman, M. T.; Fukuyama, T.; Ryu, I. Org. Lett., 2009, 11, 2457.
光マイクロリアクターを用いたフロー型光Barton反応により、脳血管攣縮抑制薬Myriceric Acid Aの鍵中間体の合成を行いました。
Microflow Photo-Radical Reaction Using a Compact Light Source: Spplication to the Barton Reaction Leading to a Key Intermediate for Myriceric Acid A, Sugimoto, A.; Fukuyama, T.; Sumino, Y.; Takagi, M.; Ryu, I., Tetrahedron, 2009, 65, 1593.
An Automated-Flow Microreactor System for Quick Optimization and Production: Application to 10- and 100-gram Order Productions of a Matrix Metalloproteinase Inhibitor Using a Sonogashira Coupling Reaction, Sugimoto, A.; Fukuyama, T.; Rahman, M. T.; Ryu, I. Tetrahedron Lett. 2009, 50, 6364.
Spurring Radical Reactions of Organic Halides with Tin Hydride and TTMSS Using Microreactors, Fukuyama, T.; Kobayashi, M.; Rahman, M. T.; Kamata, N.; Ryu, I. Org. Lett. 2008, 10, 533.
Adventures in Inner Space: Microflow Systems for Practical Organic Synthesis, Fukuyama, T.; Rahman, M. T.; Sato, M.; Ryu, I. Synlett, 2008, 151.