Publications using products from MiChS

Photoredox-Catalyzed Hydrodifluoroalkylation of Alkenes Using Difluorohaloalkyl Compounds and a Hantzsch Ester
Sumino, S.; Uno, M.; Fukuyama, T.; Ryu, I.; Matsuura, M.; Yamamoto, A.; Kishikawa, Y.
J. Org. Chem, 2017, 82, 5469 - 5474.

Scalable Flow Synthesis of [6,6]-Phenyl-C61-butyric Acid Methyl Ester (PCBM) using a Flow Photoreactor with a Sodium Lamp
Ueda, M. Imai, N.; Yoshida, S; Yasuda, H.; Fukuyama, F.; Ryu, I.
Eur. J. Org. C. 2017, 6483 - 6485.

Formal Total Synthesis of L‑Ossamine via Decarboxylative Functionalization Using Visible-Light-Mediated Photoredox Catalysis in a Flow System, Inuki, S.; Sato, K.; Fukuyama, T.; Ryu, I.; Fujimoto, Y. J. Org. Chem., 2017, 82, 1248−1253.

Flow Dehydration and Hydrogenation of Allylic Alcohols: Application to the Waste-Free Synthesis of Pristane, Furuta, A.; Hirobe, Y.; Fukuyama, T.; Ryu, T.; Manabe, Y.; Fukase, K. Eur. J. Org. Chem., 2017, 1365–1368.

Efficient Flow Fischer Esterification of Carboxylic Acids with Alcohols Using Sulfonic Acid-Functionalized Silica as Supported Catalyst, Furuta, A.; Fukuyama, T.; Ryu, I. Bull. Chem. Soc. Jpn., 2017, 90, 607–612.

A greener process for flow C–H chlorination of cyclic alkanes using in situ generation and on-site consumption of chlorine gas, Fukuyama, T.; Tokizane, M.; Matsui, M.; Ryu, I. React. Chem. Eng., 2016, 1, 613–615.

Flow Update for a Cossy Photocyclization, Fukuyama, T.; Fujita, Y.; Rashid, M. A.; Ryu, I. Org. Lett., 2016, 18, 5444−5446.

Innovative Carbonylation Methods/ Innovative Carbonylation Methods Kawamoto, T.; Fukuyama, T.; Ryu, I. Journal of Synthetic Organic Chemistry, Japan/ J. Synth. Org. Chem. Jpn. 2014, 72, 493.

Carbonylation in microflow: close encounters of CO and reactive species Fukuyama, T., Totoki, T., Ryu, I. Green Chem., 2014, 16, 2042

Adventures in Inner Space: Microflow Systems for Practical Organic Synthesis, Fukuyama, T.; Rahman, M. T.; Sato, M.; Ryu, I. Synlett, 2008, 151.

Revisiting the Bromination of C-H Bonds with Molecular Bromine by Using a Photo-Microflow System, Manabe, Y.; Kitawaki, Y.; Nagasaki, M.; Fukase, K.; Matsubara, H.; Hino, Y.; Fukuyama, T.; Ryu, I. Chem. Eur. J., 2014, 20, 12750.

Flow Update for the Carbonylation of 1-Silyl-Substituted Organolithiums under CO Pressure, Fukuyama, T.; Totoki, T.; Ryu, I. Org. Lett., 2014, 16, 5632.

Flow Carbonylation Using Near-stoichiometric Carbon Monoxide. Application to Heck Carbonylation, Akinaga, H.; Masaoka, N.; Takagi, K.; Ryu, I.; Fukuyama, T. Chem.Lett., 2014, 43, 1456.

Flow Giese Reaction Using Cyanoborohydride as a Radical Mediator, Fukuyama, T.; Kawamoto, T.; Kobayashi, M.; Ryu, I. Beilstein J. Org. Chem., 2013, 9, 1791.

Modernized Low Pressure Carbonylation Methods in Batch and Flow Employing Common Acids as a CO Source, Brancour, C., Fukuyama, T.; Mukai, Y.; Skrydstrup, T.; Ryu, I., Org. Lett., 2013, 15, 2794.

100 Gram Scale Synthesis of a Key Intermediate of Matrix Metalloproteinase Inhibitor in a Continuous-Flow System Based on a Copper-Free Sonogashira Reaction Using an Ionic Liquid as a Catalyst Support, Fukuyama, T.; Rahman, M. T.; Sumino, Y.; Ryu, I. Synlett, 2012, 23, 2279.

Nitroxide-Mediated Polymerization of Styrene, Butyl Acrylate, or Methyl Methacrylate by Microflow Reactor Technology, Fukuyama, T.; Kajihara, Y.; Ryu, I.; Studer, A., Synthesis 2012, 44, 16 pp. 2555 – 2559.

Koch–Haaf Reaction of Adamantanols in an Acid-tolerant Hastelloy-made Microreactor, Fukuyama, T.; Mukai, Y.; Ryu, I. Beilstein J. Org. Chem., 2011, 7, 1288.

Continuous Microflow [2 + 2] Photocycloaddition Reactions Using Energy-saving Compact Light Sources, Fukuyama, T.; Kajihara, Y.; Hino, Y.; Ryu, I.; J. Flow Chem., 2011, 1, 40.

Microflow photo-radical chlorination of cycloalkanes , Matsubara, H.; Hino, Y.; Tokizane, M.; Ryu, I., Chemical Engineering Journal, 2011, 167, 567.

Monolithic and Flexible Polyimide Film Microreactors for Organic Microchemical Applications Fabricated by Laser Ablation, Min, K. I.; Lee, T. H.; Park, C. P.; Wu, Z. W.; Girault, H. H.; Ryu, I.; Fukuyama, T., Mukai, Y., Kim, D. P., Angew. Chem. Int. Ed., 2010, 49, 7063.

Addition of Allyl Bromide to Phenylacetylene Catalyzed by Palladium on Alumina and its Application to a Continuous Flow Synthesis, Fukuyama, T.; Kippo, T.; Ryu, I.; Sagae, T. Research on Chemical Intermediates, 2009, 35, 1053.

Microflow Radical Carboaminoxylations with a Novel Alkoxyamine Wienhoefer, I. C.; Studer, A.; Rahman, M. T.; Fukuyama, T.; Ryu, I. Org. Lett., 2009, 11, 2457.

Microflow Photo-Radical Reaction Using a Compact Light Source: Spplication to the Barton Reaction Leading to a Key Intermediate for Myriceric Acid A, Sugimoto, A.; Fukuyama, T.; Sumino, Y.; Takagi, M.; Ryu, I., Tetrahedron, 2009, 65, 1593.

Role of Flow Microreactors for Pharmaceutical Production: Screening of Reaction Conditions and Sample Preparation, Yukihito Sumino; Takahide Fukuyama Journal of Synthetic Organic Chemistry, Japan / 2012 Volume 70 Issue 9 Pages 896-907

Spurring Radical Reactions of Organic Halides with Tin Hydride and TTMSS Using Microreactors, Fukuyama, T.; Kobayashi, M.; Rahman, M. T.; Kamata, N.; Ryu, I. Org. Lett. 2008, 10, 533.

An Automated-Flow Microreactor System for Quick Optimization and Production: Application to 10- and 100-gram Order Productions of a Matrix Metalloproteinase Inhibitor Using a Sonogashira Coupling Reaction, Sugimoto, A.; Fukuyama, T.; Rahman, M. T.; Ryu, I. Tetrahedron Lett. 2009, 50, 6364.